Description

(S)-Timolol Maleate CAS NO 26921-17-5 is the pharmacologically active enantiomer of the non-selective β-adrenergic receptor blocking agent, Timolol. This high-purity chiral intermediate is critical for the development and manufacturing of enantiomerically pure ophthalmic and cardiovascular pharmaceuticals. It is primarily required by pharmaceutical R&D laboratories and API manufacturers focused on producing advanced, targeted therapies with improved efficacy and reduced side-effect profiles.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Key chiral building block for the production of (S)-Timolol, the therapeutically active form.
• Ophthalmic Solutions: Manufacturing of prescription eye drops used to treat conditions like glaucoma and ocular hypertension.
• Cardiovascular Drug Formulation: Research and production of medications for hypertension, angina pectoris, and myocardial infarction prophylaxis.
• Chiral Reference Standard: Serves as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical labs.
• Pharmacological Research: Used in preclinical and clinical studies to investigate β-blocker mechanisms, pharmacokinetics, and enantiomer-specific effects.
• Process Chemistry Development: Employed in optimizing asymmetric synthesis routes and scaling up enantioselective manufacturing processes.

Basic Information

Product Name	(S)-Timolol Maleate
CAS No.	26921-17-5
Molecular Formula	C17H28N4O7S
Molecular Weight	432.49 g/mol
Synonyms	(S)-(-)-Timolol Maleate; (S)-Timolol Hydrogen Maleate; L-Timolol Maleate; (S)-1-(tert-Butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol Maleate; Timolol (S)-Maleate; (2S)-3-(1,1-Dimethylethyl)amino-2-hydroxypropyl 4-morpholinyl-1,2,5-thiadiazol-3-yl ether maleate; MK-950 Maleate; Blocadren (S)-Maleate
EINECS	Contact for details

Quality Control

Our (S)-Timolol Maleate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D and API synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.