Description

(+)-1-(tert-Butylamino)-3-[(4-Morpholino-1,2,5-Thiadiazol-3-Yl)Oxy]Propan-2-Ol is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound matters for its role as a key building block in the development of active pharmaceutical ingredients (APIs), particularly those targeting cardiovascular and neurological pathways. Pharmaceutical R&D teams and fine chemical manufacturers need this material to ensure the stereochemical integrity and efficacy of their final drug products.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of β-adrenergic blocking agents (β-blockers).
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for novel cardiovascular and neurological therapeutics.
• Asymmetric Synthesis: Serves as a valuable chiral synthon in medicinal chemistry for constructing complex molecules with defined stereochemistry.
• Chemical Reference Standard: Employed as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Process Chemistry & Scale-Up: Utilized in optimizing synthetic routes from laboratory to pilot and commercial manufacturing scales.
• Life Science Research: Applied in biochemical and pharmacological studies to investigate receptor interactions and signaling pathways.

Basic Information

Item	Details
Product Name	(+)-1-(tert-Butylamino)-3-[(4-Morpholino-1,2,5-Thiadiazol-3-Yl)Oxy]Propan-2-Ol
CAS No.	26839-76-9
Molecular Formula	C15H28N4O3S
Molecular Weight	344.47 g/mol
Synonyms	(+)-1-(tert-Butylamino)-3-[(4-Morpholinyl-1,2,5-thiadiazol-3-yl)oxy]-2-propanol; (S)-Timolol Intermediate; (+)-Timolol Precursor; (S)-1-(tert-Butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol; Levobunolol Related Compound; CAS 26839-76-9; (S)-enantiomer of the Timolol amine intermediate
EINECS	Contact for details

Quality Control

Our (+)-1-(tert-Butylamino)-3-[(4-Morpholino-1,2,5-Thiadiazol-3-Yl)Oxy]Propan-2-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. All products undergo rigorous analytical testing, including chiral purity verification by HPLC, to meet the exacting standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.