Description

Trifluoroacetyldaunomycin is a chemically modified derivative of the anthracycline antibiotic daunomycin, where a trifluoroacetyl group has been introduced. This modification is significant as it can alter the compound's pharmacological properties, stability, and interaction with biological targets, making it a valuable intermediate for advanced pharmaceutical research and development. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of novel anticancer agents, prodrug development, and structure-activity relationship (SAR) studies. The compound, identified by CAS number 26388-52-3, serves as a critical building block for exploring new therapeutic avenues in oncology.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel anthracycline-based chemotherapeutic agents.
• Prodrug Development: Used in studies to create prodrugs with improved selectivity, reduced side effects, or enhanced bioavailability compared to parent compounds.
• Biochemical Research: Employed as a tool compound to investigate the mechanisms of action, resistance, and metabolism of anthracycline drugs.
• Structure-Activity Relationship (SAR) Studies: Essential for modifying the daunomycin scaffold to understand how structural changes impact anticancer activity and toxicity.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Academic Research: Utilized in university and institutional labs for fundamental studies in medicinal chemistry and cancer biology.

Basic Information

Product Name	Trifluoroacetyldaunomycin
CAS No.	26388-52-3
Molecular Formula	C₃₂H₂₉F₃NO₁₁
Molecular Weight	660.57 g/mol
Synonyms	Daunomycin Trifluoroacetate; 3'-Trifluoroacetyldaunomycin; 3'-Trifluoroacetyldaunorubicin; 3'-O-Trifluoroacetyldaunorubicin; 3'-O-Trifluoroacetyldaunomycin; N-Trifluoroacetyldaunorubicin; Daunorubicin 3'-Trifluoroacetate; (1S,3S)-3-Acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside 3-trifluoroacetate
EINECS	Contact for details

Quality Control

Our Trifluoroacetyldaunomycin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications such as assay purity, identity, and impurity profile to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.