Description

Dexchlorpheniramine is a potent, selective histamine H1-receptor antagonist belonging to the alkylamine class of antihistamines. This active pharmaceutical ingredient (API) is valued for its efficacy in managing allergic conditions with a favorable therapeutic profile. It is a critical raw material for pharmaceutical manufacturers producing antihistamine formulations, particularly for the global market. The compound is supplied under the identifier CAS NO 25523-97-1.

Application

Dexchlorpheniramine serves as the core active ingredient in a variety of therapeutic products. Its primary and derived applications include:

• Pharmaceutical Antihistamine Tablets and Capsules: Formulated for the systemic treatment of seasonal and perennial allergic rhinitis, allergic conjunctivitis, and urticaria.
• Pediatric Syrups and Oral Solutions: Developed in age-appropriate dosages for safe and effective allergy relief in children.
• Combination Cold & Flu Medications: Used in multi-symptom relief formulas alongside decongestants, analgesics, and antitussives.
• Veterinary Pharmaceutical Preparations: Incorporated into treatments for allergic reactions and pruritus in companion animals.
• Clinical Research and Reference Standards: Serves as a high-purity chemical standard for analytical method development, pharmacokinetic studies, and bioequivalence testing.

Basic Information

Product Name	Dexchlorpheniramine
CAS No.	25523-97-1
Molecular Formula	C16H19ClN2
Molecular Weight	274.79 g/mol
Synonyms	Dexchlorpheniramine Maleate (common salt form); (+)-Chlorpheniramine; d-Chlorpheniramine; Dexchlorpheniramine Maleate; (3S)-3-(4-Chlorophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine; S(+)-Chlorpheniramine; Polaronil; Polaramin; Dexchlorpheniramine (base)
EINECS	247-077-5

Quality Control

Our Dexchlorpheniramine is manufactured and tested to meet stringent pharmaceutical-grade standards. Quality assurance protocols are designed to ensure identity, purity, strength, and composition, aligning with ICH guidelines and current Good Manufacturing Practices (cGMP). A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing results for assay, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). The container should be kept in a dry, well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any individual impurity ≤ 0.5%
Water (KF Titration)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.