Description

Clobetasone Butyrate is a synthetic corticosteroid belonging to the glucocorticoid class, recognized for its potent anti-inflammatory and immunosuppressive properties. This high-purity active pharmaceutical ingredient (API) is critical for the development of effective topical dermatological treatments. It is primarily required by pharmaceutical manufacturers and research institutions focused on creating advanced therapies for inflammatory skin conditions.

Application

• Topical Corticosteroid Formulations: Primary active ingredient in creams, ointments, and lotions for treating inflammatory skin disorders such as eczema, psoriasis, and dermatitis.
• Dermatological Research: Key reference standard and building block in R&D for novel anti-inflammatory drug candidates and delivery systems.
• Veterinary Pharmaceuticals: Used in topical preparations for managing skin inflammation and allergic reactions in animals.
• Compounding Pharmacy: Sourced by specialized pharmacies for preparing customized topical medication blends for specific patient needs.

Basic Information

Product Name	Clobetasone Butyrate
CAS No.	25122-57-0
Molecular Formula	C26H32ClFO5
Molecular Weight	478.98 g/mol
Synonyms	Clobetasone 17-Butyrate; (11β,16β)-21-Chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione 17-Butyrate; Clobetasone Butyrate (USP); Clobetasone Butyrate (EP); Clobetasone 17α-Butyrate; 21-Chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-butyrate; Trimovate (Trade Name)
EINECS	Contact for details

Quality Control

Our Clobetasone Butyrate is manufactured under strict quality management systems. It undergoes comprehensive analytical testing to meet or exceed relevant pharmacopeial standards, including USP and EP monographs. A detailed Certificate of Analysis (COA) is provided with each batch, confirming identity, purity, and impurity profiles to ensure suitability for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.