Description

21-Chloro-9-Fluoro-11β,17-Dihydroxy-16α-Methylpregna-1,4-Diene-3,20-Dione 17-Propionate is a high-purity synthetic steroid derivative, primarily utilized as a critical pharmaceutical intermediate. This compound is valued for its role in the synthesis of advanced corticosteroid APIs, where its specific halogenated and esterified structure imparts targeted biological activity. It is essential for research and development laboratories and manufacturing facilities focused on anti-inflammatory, dermatological, and ophthalmic therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potent topical and systemic corticosteroids.
• Active Pharmaceutical Ingredient (API) Development: Used in R&D for creating new steroid-based drug candidates with modified potency and pharmacokinetics.
• Reference Standard: Serves as an analytical standard for quality control and regulatory testing in pharmaceutical manufacturing.
• Biochemical Research: Employed in studies investigating steroid receptor interactions and metabolic pathways.
• Veterinary Medicine: Potential use in developing anti-inflammatory treatments for animals.

Basic Information

Product Name	21-Chloro-9-Fluoro-11β,17-Dihydroxy-16α-Methylpregna-1,4-Diene-3,20-Dione 17-Propionate
CAS No.	25122-52-5
Molecular Formula	C25H30ClFO5
Molecular Weight	464.96 g/mol
Synonyms	Clobetasol 17-Propionate; Clobetasol Propionate Impurity; 21-Chloro-9α-fluoro-11β,17α-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17-propionate; 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate 21-chloro; Clobetasol Propionate Related Compound A; (11β,16α)-21-Chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione 17-propionate
EINECS	Contact for details

Quality Control

Our 21-Chloro-9-Fluoro-11β,17-Dihydroxy-16α-Methylpregna-1,4-Diene-3,20-Dione 17-Propionate is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.