Description

Clobetasolbutyrate is a potent synthetic corticosteroid ester, a key pharmaceutical intermediate in the synthesis of advanced topical corticosteroids. Its primary commercial value lies in its critical role as a precursor for high-potency anti-inflammatory and immunosuppressive active pharmaceutical ingredients (APIs). This compound is essential for manufacturers in the pharmaceutical industry, particularly those developing and producing prescription-strength dermatological creams, ointments, and solutions for treating severe skin conditions such as psoriasis, eczema, and dermatitis.

Application

• Pharmaceutical Intermediate: Primary use as a key building block in the synthesis of Clobetasol Propionate and other high-potency corticosteroid APIs.
• Topical Corticosteroid Production: Manufacture of prescription-strength creams, ointments, gels, and lotions for severe inflammatory skin disorders.
• Dermatological Formulations: Serves as a critical raw material for compounding pharmacies and large-scale pharmaceutical manufacturers specializing in dermatology.
• Research & Development: Used in pharmaceutical R&D for developing new corticosteroid derivatives and studying structure-activity relationships (SAR).
• Veterinary Medicine: Potential application in the formulation of high-potency anti-inflammatory treatments for animals.

Basic Information

Product Name	Clobetasolbutyrate
CAS No.	25122-47-8
Molecular Formula	C26H32ClFO5
Molecular Weight	478.98 g/mol
Synonyms	Clobetasol Butyrate; Clobetasone Butyrate; (11β,16β)-21-Chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione 17-butyrate; 21-Chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-butyrate; SQ-18539; CBF; Clobetasol 17-butyrate
EINECS	Contact for details

Quality Control

Our Clobetasolbutyrate is manufactured under strict quality management systems, targeting specifications suitable for pharmaceutical intermediate applications. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced chromatographic methods. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure full traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.