Description

Clobetasol Propionate is a synthetic corticosteroid of the glucocorticoid class, recognized for its potent anti-inflammatory and immunosuppressive properties. This high-potency active pharmaceutical ingredient (API) is critical for formulating effective topical treatments for severe dermatological conditions. It is primarily utilized by pharmaceutical manufacturers and compounding pharmacies specializing in dermatology and steroid therapy. Consistent quality and reliable supply are paramount for ensuring the safety and efficacy of the final medicinal products.

Application

• Topical Corticosteroid Formulations: Primary API in creams, ointments, gels, and lotions for treating severe inflammatory skin disorders such as psoriasis, eczema, and dermatitis.
• Scalp Solutions: Key ingredient in medicated shampoos, foams, and solutions for managing scalp psoriasis and severe seborrheic dermatitis.
• Compounding Pharmacy: Sourced by specialized pharmacies for preparing customized dosage forms to meet specific patient needs under medical supervision.
• Veterinary Dermatology: Used in topical preparations for managing inflammatory skin conditions in animals.
• Clinical Research: Serves as a reference standard and raw material in pharmaceutical R&D for developing new topical steroid delivery systems.

Basic Information

Product Name	Clobetasol Propionate
CAS No.	25122-46-7
Molecular Formula	C25H32ClFO5
Molecular Weight	466.97 g/mol
Synonyms	Clobetasol 17-propionate; Clobetasone Propionate (obsolete); 21-Chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate; Dermovate (Trade Name); Temovate (Trade Name); (11β,16β)-21-Chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione 17-propionate; CGP 14458; GR 2/1214
EINECS	246-634-0

Quality Control

Our Clobetasol Propionate is manufactured and tested to meet stringent pharmacopeial standards, including USP and EP monographs. Every batch undergoes comprehensive analytical testing for identity, purity, and impurity profiles using validated methods such as HPLC and IR spectroscopy. A Certificate of Analysis (COA) detailing all test results is provided to ensure full traceability and compliance with cGMP guidelines for pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and potency.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Conforms to standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Specific Optical Rotation	+99° to +105°
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Sulfated Ash	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.