Description

Clobetasol is a potent synthetic corticosteroid widely recognized for its exceptional anti-inflammatory and immunosuppressive properties. This high-purity active pharmaceutical ingredient (API) is critical for formulators requiring reliable and consistent potency in their finished products. It is primarily utilized by pharmaceutical manufacturers and compounding pharmacies specializing in dermatological treatments. The compound's efficacy makes it a cornerstone in the development of topical medications for severe skin conditions.

Application

• Topical Corticosteroid Formulations: Primary API in creams, ointments, lotions, and foams for treating severe inflammatory skin disorders such as psoriasis, eczema, and lichen planus.
• Scalp Solutions: Key ingredient in medicated shampoos and solutions for managing scalp psoriasis and severe seborrheic dermatitis.
• Dermatological Research: Used as a reference standard and active component in preclinical and clinical research for new anti-inflammatory therapies.
• Compounding Pharmacy: Sourced by pharmacies for the preparation of customized prescription-strength topical medications.
• Veterinary Pharmaceuticals: Employed in veterinary medicine for the treatment of severe dermatological conditions in animals.

Basic Information

Product Name	Clobetasol
CAS No.	25122-41-2
Molecular Formula	C25H32ClFO5
Molecular Weight	466.97 g/mol
Synonyms	Clobetasol Propionate; Clobetasone; Dermovate; Temovate; (11β,16β)-21-Chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione 17-propionate; 21-Chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate; CGP 9555
EINECS	246-634-3

Quality Control

Our Clobetasol is manufactured under strict quality management systems to ensure it meets the highest standards for pharmaceutical use. Each batch is tested against rigorous specifications, including identity, purity, and impurity profiles, aligning with major pharmacopoeial guidelines. A comprehensive Certificate of Analysis (COA) documenting all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to almost white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.