Description

21-Chloro-9-Fluoro-11β,17-Dihydroxy-16β-Methylpregn-4-Ene-3,20-Dione 17-Propionate CAS NO 25120-99-4 is a high-purity synthetic steroid derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in its specific structural modifications, which are essential for developing potent and targeted corticosteroid-based active pharmaceutical ingredients (APIs). This compound is primarily needed by pharmaceutical R&D laboratories and manufacturers specializing in the synthesis of anti-inflammatory and immunosuppressive medications.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel corticosteroid APIs.
• Anti-inflammatory Drug Development: Used in research and production of potent topical and systemic anti-inflammatory agents.
• Immunosuppressant Synthesis: Serves as a precursor for drugs designed to modulate immune system responses.
• Dermatological Preparations: Found in the development chain for advanced creams and ointments targeting skin conditions.
• Respiratory Medicine: Utilized in creating inhaled corticosteroids for asthma and COPD treatments.
• Research & Development: A valuable reference standard and starting material for medicinal chemistry and pharmacological studies.

Basic Information

Product Name	21-Chloro-9-Fluoro-11β,17-Dihydroxy-16β-Methylpregn-4-Ene-3,20-Dione 17-Propionate
CAS No.	25120-99-4
Molecular Formula	C25H32ClFO5
Molecular Weight	466.97 g/mol
Synonyms	9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate; 21-Chloro-9α-fluoro-11β,17α-dihydroxy-16β-methylpregna-4-ene-3,20-dione 17-propionate; Clocortolone 17-propionate; Clocortolone pivalate related compound; 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-chloro-17-propionate; Clocortolone propionate impurity; Steroid intermediate 25120-99-4
EINECS	Contact for details

Quality Control

Our 21-Chloro-9-Fluoro-11β,17-Dihydroxy-16β-Methylpregn-4-Ene-3,20-Dione 17-Propionate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.