Description

Icomethasone 21-Acetate is a synthetic corticosteroid derivative and a key pharmaceutical intermediate. This compound is valued for its role in the synthesis of more complex steroid-based active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development and production of anti-inflammatory and immunosuppressive medications.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of potent corticosteroid APIs.
• Anti-inflammatory Drug Research: Used in R&D for developing novel topical and systemic anti-inflammatory agents.
• Immunosuppressant Synthesis: Serves as a precursor in the manufacture of drugs that modulate the immune system.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Biochemical Research: Used in academic and industrial research to study steroid hormone pathways and receptor interactions.
• Process Development: Integral to scaling up and optimizing manufacturing processes for steroid-based pharmaceuticals.

Basic Information

Item	Detail
Product Name	Icomethasone 21-Acetate
CAS No.	24916-91-4
Molecular Formula	C24H31FO6
Molecular Weight	434.50 g/mol
Synonyms	9α-Fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate; 9α-Fluoro-11β,16α,17α,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 21-acetate; Icomethasone Acetate; 9α-Fluoro-16α-hydroxyprednisolone 21-acetate; (11β,16α)-9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate
EINECS	Contact for details

Quality Control

Our Icomethasone 21-Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets stringent specifications for pharmaceutical intermediates. A Certificate of Analysis (COA) documenting all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.