Description

11Beta,17,21-Trihydroxypregn-4-Ene-3,20-Dione 21-Pivalate is a high-purity steroid derivative, specifically the 21-pivalate ester of hydrocortisone. This compound is a critical pharmaceutical intermediate valued for its role in the synthesis of more complex, potent corticosteroid APIs. It is primarily required by manufacturers in the pharmaceutical and life sciences sectors for research and development, process chemistry, and the production of advanced steroid-based therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potent topical and systemic corticosteroid drugs.
• Process Chemistry & R&D: Used in laboratory-scale research and process development for novel steroid analog creation.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in API manufacturing.
• Biochemical Research: Employed in studies investigating steroid metabolism, receptor binding, and enzymatic conversion pathways.

Basic Information

Product Name	11Beta,17,21-Trihydroxypregn-4-Ene-3,20-Dione 21-Pivalate
CAS No.	24869-41-8
Molecular Formula	C₂₆H₃₈O₆
Molecular Weight	446.58 g/mol
Synonyms	Hydrocortisone 21-Pivalate; Cortisol 21-Pivalate; 11β,17,21-Trihydroxypregn-4-ene-3,20-dione 21-pivalate; 21-(2,2-Dimethylpropanoyloxy)-11β,17-dihydroxypregn-4-ene-3,20-dione; Pivalic acid hydrocortisone ester; NSC 10483; Hydrocortisone pivalate (ester)
EINECS	Contact for details

Quality Control

Our 11Beta,17,21-Trihydroxypregn-4-Ene-3,20-Dione 21-Pivalate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets exacting standards suitable for pharmaceutical R&D and intermediate use. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.