Description

17,21-Dihydroxypregna-1,4-Diene-3,11,20-Trione 21-(Hydrogen Succinate) is a high-purity steroid derivative and a key pharmaceutical intermediate. This compound is critical for the synthesis of advanced corticosteroid APIs, where its specific structure enables targeted pharmacological activity. It is primarily required by pharmaceutical R&D laboratories and manufacturing facilities focused on developing and producing anti-inflammatory and immunosuppressive medications.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of potent corticosteroid active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for the development and structural modification of new steroid-based therapeutics.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical analysis.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial manufacturing of steroid drugs.

Basic Information

Product Name	17,21-Dihydroxypregna-1,4-Diene-3,11,20-Trione 21-(Hydrogen Succinate)
CAS No.	24808-87-5
Molecular Formula	C₂₅H₃₂O₉
Molecular Weight	476.52 g/mol
Synonyms	Prednisolone 21-Hydrogen Succinate; Prednisolone Succinate; Prednisolone 21-Hemisuccinate; 11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione 21-Hemisuccinate; NSC 106977; δ1-Cortisol 21-Hemisuccinate; 1,4-Pregnadiene-11β,17α,21-triol-3,20-dione 21-Hemisuccinate
EINECS	Contact for details

Quality Control

Our 17,21-Dihydroxypregna-1,4-Diene-3,11,20-Trione 21-(Hydrogen Succinate) is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.