Description

4-Fluorocinnamonitrile is a versatile fluorinated aromatic nitrile building block, essential for advanced organic synthesis. Its unique structure, featuring both a fluorine substituent and a cyano group on a styrene backbone, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, including kinase inhibitors, anti-inflammatory agents, and CNS-active compounds.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and pesticides where the fluorine atom enhances bioavailability and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated mesogens and electron-transport materials in display and lighting technologies.
• Polymer & Resin Modifier: Incorporated into specialty polymers to improve chemical resistance, thermal stability, and surface properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.
• Chemical Research & Development: A valuable reagent for exploring new fluorination methodologies and constructing diverse chemical libraries for screening.

Basic Information

Product Name	4-Fluorocinnamonitrile
CAS No.	24654-48-6
Molecular Formula	C9H6FN
Molecular Weight	147.15 g/mol
Synonyms	(E)-3-(4-Fluorophenyl)acrylonitrile; 4-Fluorocin-namonitrile; trans-4-Fluorocinnamonitrile; (E)-3-(4-Fluorophenyl)-2-propenenitrile; 4-Fluorobenzylideneacetonitrile; p-Fluorocinnamonitrile; 4-Fluorostyryl cyanide; (E)-4-Fluorocinnamnitrile
EINECS	Contact for details

Quality Control

Our 4-Fluorocinnamonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is characterized by advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	85 - 89 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.