Description

Nivacortol CAS NO 24358-76-7 is a synthetic corticosteroid intermediate of significant importance in pharmaceutical manufacturing. This compound serves as a critical building block in the synthesis of potent anti-inflammatory and immunosuppressive active pharmaceutical ingredients (APIs). It is essential for research and production facilities focused on developing advanced steroid-based therapeutics. Our supply ensures high purity and batch-to-batch consistency for reliable process integration.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel corticosteroid drugs and prodrugs.
• Anti-inflammatory API Synthesis: Used in the manufacturing pathway for potent glucocorticoid receptor agonists.
• Research & Development: Serves as a standard or starting material in medicinal chemistry for exploring new steroid derivatives.
• Process Chemistry: Employed in scale-up and optimization studies for commercial pharmaceutical production.
• Reference Standard: Can be utilized as an analytical standard for quality control and method development in steroid analysis.

Basic Information

Item	Detail
Product Name	Nivacortol
CAS No.	24358-76-7
Molecular Formula	C22H30O4
Molecular Weight	358.47 g/mol
Synonyms	9α-Fluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione; 9α-Fluoro-16α-methylprednisolone; 9α-Fluoro-16α-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione; Fluocortolone Impurity; Nivacortolum; 9-Fluoro-16α-methylprednisolone; 9α-Fluoro-16α-methyl-δ1-hydrocortisone
EINECS	Contact for details

Quality Control

Our Nivacortol is manufactured under a strict quality management system to ensure it meets the exacting standards required for pharmaceutical intermediates. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling. Certificates of Analysis (COA) documenting all test results are provided to guarantee traceability and compliance with cGMP principles where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.