Description

Halocortolone is a synthetic corticosteroid with potent anti-inflammatory and immunosuppressive properties. This compound is a critical active pharmaceutical ingredient (API) for the development of topical dermatological formulations. It is primarily utilized by pharmaceutical manufacturers and research institutions in the life sciences sector. The product is supplied under stringent quality control to ensure consistency and efficacy for advanced therapeutic applications.

Application

• Primary Active Pharmaceutical Ingredient (API) in topical corticosteroid creams and ointments.
• Key component in dermatological preparations for treating inflammatory skin conditions such as eczema, psoriasis, and dermatitis.
• Used in clinical and preclinical research for studying glucocorticoid receptor activity and anti-inflammatory mechanisms.
• Formulation development for veterinary medicinal products targeting skin inflammation in animals.
• Reference standard in analytical laboratories for quality control and method development.
• Starting material for the synthesis of more complex steroid derivatives in pharmaceutical chemistry.

Basic Information

Product Name	Halocortolone
CAS No.	24320-27-2
Molecular Formula	C₂₂H₂₈ClFO₅
Molecular Weight	426.91 g/mol
Synonyms	Halocortolone; 9α-Fluoro-11β,17α,21-trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-acetate; 6α-Methyl-9α-fluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate; 9α-Fluoro-6α-methylprednisolone 21-acetate; NSC-121055; U-8226; Halocortolonum; Halocortolon
EINECS	Contact for details

Quality Control

Our Halocortolone is manufactured and tested to meet high-purity standards suitable for pharmaceutical development. Quality assurance protocols include identity confirmation, purity assessment, and control of specified impurities. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing results against established specifications. Our quality system is designed to support compliance with cGMP and relevant ICH guidelines for APIs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept under conditions that minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.