Description

9-Chloro-6Alpha,11Beta-Difluoro-21-Hydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Valerate is a high-purity synthetic corticosteroid derivative, also known as Halobetasol Valerate. This compound is a critical active pharmaceutical ingredient (API) valued for its potent anti-inflammatory and immunosuppressive properties. It is primarily required by pharmaceutical manufacturers for the development and production of topical dermatological formulations, such as creams and ointments, used to treat severe skin conditions like psoriasis and eczema.

Application

• Active Pharmaceutical Ingredient (API) for topical corticosteroid creams and ointments.
• Dermatological Preparations targeting psoriasis, eczema, contact dermatitis, and other inflammatory skin disorders.
• Pharmaceutical Intermediates in the synthesis of more complex steroid-based therapeutics.
• Research & Development for novel drug delivery systems and new anti-inflammatory agents.
• Reference Standard for quality control and analytical testing in pharmaceutical laboratories.
• Veterinary Medicine for topical treatment of inflammatory skin conditions in animals.

Basic Information

Product Name	9-Chloro-6Alpha,11Beta-Difluoro-21-Hydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Valerate
CAS No.	24320-24-9
Molecular Formula	C27H36ClF2O5
Molecular Weight	505.03 g/mol
Synonyms	Halobetasol Valerate; Halobetasol 17-Valerate; Ultravate (Trade Name); (6α,11β,16β)-21-(3-Methylbutanoyloxy)-9-chloro-6-fluoro-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione; 9-Chloro-6α-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-valerate; 9-Chloro-6α-fluoro-11β-hydroxy-16α-methyl-17α-[(1-oxopentyl)oxy]pregna-1,4-diene-3,20-dione; CGP 14458; SQ 18566
EINECS	Contact for details

Quality Control

Our Halobetasol Valerate is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical actives. Quality is assured through comprehensive analytical testing, including HPLC for purity, identification by IR and NMR, and control of specified impurities. A Certificate of Analysis (COA) is provided with each batch, detailing compliance with in-house specifications aligned with major pharmacopoeial standards. We support customer audits and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere packing.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.