Description

9Beta,11Beta-Epoxy-6Alpha-Fluoro-17,21-Dihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione is a high-purity synthetic steroid intermediate of significant importance in advanced pharmaceutical manufacturing. This compound serves as a critical precursor in the synthesis of potent topical corticosteroids, enabling precise control over anti-inflammatory and immunosuppressive activity. It is primarily required by pharmaceutical R&D laboratories and API (Active Pharmaceutical Ingredient) producers focused on developing and scaling up next-generation dermatological and ophthalmic treatments.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced corticosteroid APIs like Halobetasol Propionate and related analogues.
• Anti-inflammatory Drug Research: Used in preclinical and clinical research for developing new topical agents with enhanced potency and reduced systemic side effects.
• Dermatological Formulations: Serves as a starting material for active ingredients in creams, ointments, and lotions for treating psoriasis, eczema, and dermatitis.
• Ophthalmic Steroid Production: Integral to manufacturing steroid components used in eye drops for managing ocular inflammation.
• Chemical Reference Standard: Employed as a high-purity standard in analytical laboratories for quality control and regulatory testing of finished pharmaceutical products.
• Process Chemistry & Scale-Up: Utilized in process optimization and pilot-scale synthesis within pharmaceutical development pipelines.

Basic Information

Product Name	9Beta,11Beta-Epoxy-6Alpha-Fluoro-17,21-Dihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione
CAS No.	23961-95-7
Molecular Formula	C22H27FO6
Molecular Weight	406.45 g/mol
Synonyms	21-Hydroxy-9β,11β-epoxy-6α-fluoro-16α-methylpregna-1,4-diene-3,20-dione; 9β,11β-Epoxy-6α-fluoro-16α-methylprednisolone; Halobetasol Intermediate; 6α-Fluoro-9β,11β-epoxy-16α-methylprednisolone; U-82247; (6α,9β,11β,16α)-9,11-Epoxy-6-fluoro-17,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
EINECS	Contact for details

Quality Control

Our 9Beta,11Beta-Epoxy-6Alpha-Fluoro-17,21-Dihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Production can be aligned with cGMP (current Good Manufacturing Practice) standards for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider using a desiccator or storing under an inert atmosphere to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.