Description

2-Chloro-6Alpha,9-Difluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Acetate is a high-purity synthetic corticosteroid intermediate of significant pharmaceutical importance. This compound is valued for its role as a key precursor in the synthesis of potent anti-inflammatory and immunosuppressive active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical R&D laboratories and manufacturing facilities engaged in the production of advanced steroid-based therapeutics. Our supply ensures the stringent quality and consistency demanded for critical pharmaceutical synthesis.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of high-potency topical and systemic corticosteroids.
• Active Pharmaceutical Ingredient (API) Development: Serves as a key starting material (KSM) or advanced intermediate in the research and development of novel steroidal drugs.
• Anti-inflammatory Drug Synthesis: Specifically used in manufacturing pathways for drugs targeting dermatitis, psoriasis, asthma, and other inflammatory conditions.
• Process Chemistry & Scale-Up: Utilized in process optimization and pilot-scale production for established and new chemical entities (NCEs).
• Reference Standard: Can be supplied as a high-purity standard for analytical method development, validation, and quality control testing.
• Biochemical Research: Used in academic and industrial research to study glucocorticoid receptor activity and metabolic pathways.

Basic Information

Product Name	2-Chloro-6Alpha,9-Difluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Acetate
CAS No.	23961-22-0
Molecular Formula	C₂₄H₂₉ClF₂O₆
Molecular Weight	486.94 g/mol
Synonyms	Clobetasol 21-Acetate; Clobetasol Acetate; 21-Acetoxyclobetasol; 2-Chloro-6α,9-difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate; 6α,9-Difluoro-11β,17,21-trihydroxy-16α-methyl-2-chloropregna-1,4-diene-3,20-dione 21-acetate; (11β,16α)-2-Chloro-6,9-difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 21-acetate; Clobetasol propionate intermediate; Clobetasone butyrate related compound
EINECS	Contact for details

Quality Control

Our 2-Chloro-6Alpha,9-Difluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical intermediates. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.