Description

Tetrabutylammonium Hydrogen Difluoride is a versatile and highly reactive organofluorine reagent, primarily used as a convenient source of fluoride ion in organic synthesis. Its significance lies in its dual functionality, acting as both a phase-transfer catalyst and a mild fluorinating agent, which enables critical transformations under relatively mild conditions. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries, where precise fluorination and catalysis are required.

Application

• Nucleophilic Fluorination Reactions: A key reagent for the synthesis of alkyl fluorides and aryl fluorides via nucleophilic aromatic substitution (SNAr).
• Phase-Transfer Catalyst (PTC): Facilitates reactions between reagents in immiscible phases, particularly in halogen exchange (halex) reactions to prepare fluorinated aromatic compounds.
• Desilylation Agent: Efficiently cleaves silicon-protecting groups (e.g., tert-butyldimethylsilyl / TBS) in complex molecule synthesis.
• Electrolyte Additive: Investigated for use in specialty batteries and electrochemical systems due to its ionic liquid-like properties.
• Polymer Modification: Used in the surface treatment and functionalization of polymers to introduce fluorine-containing groups.
• Organic Synthesis Intermediate: Serves as a precursor for other tetrabutylammonium salts and fluorinating reagents.

Basic Information

Product Name	Tetrabutylammonium Hydrogen Difluoride
CAS No.	23868-34-0
Molecular Formula	C16H36F2N
Molecular Weight	279.47 g/mol
Synonyms	TBAF·HF; Tetrabutylammonium Dihydrogen Trifluoride (common misnomer); Tetra-n-butylammonium Hydrogen Difluoride; TBABF; N,N,N-Tributyl-1-butanaminium Hydrogen Difluoride; Fluoride, hydrogen, tetrabutylammonium; Tetrabutylammonium bifluoride; TBAHF
EINECS	Contact for details

Quality Control

Our Tetrabutylammonium Hydrogen Difluoride is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee supply reliability and product traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (Titration)	≥ 98.0 %
Water Content (KF)	≤ 1.0 %
Heavy Metals (as Pb)	≤ 10 ppm
Residue on Ignition	≤ 0.1 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.