Description

6α,9α-Difluoroprednisolone 17-Acetate is a synthetic fluorinated corticosteroid derivative, a key intermediate in the synthesis of potent anti-inflammatory pharmaceutical agents. Its value lies in providing a critical building block for the development of advanced topical and systemic corticosteroid medications. This high-purity intermediate is essential for pharmaceutical R&D laboratories and manufacturers specializing in steroid-based therapeutics, particularly those targeting dermatological and inflammatory conditions.

Application

• Pharmaceutical Intermediate: Primary use as a crucial synthetic precursor in the manufacture of advanced corticosteroid APIs (Active Pharmaceutical Ingredients).
• Anti-inflammatory Drug Synthesis: Used in the research and production of potent topical corticosteroids for treating skin conditions like eczema, psoriasis, and dermatitis.
• Steroid Prodrug Development: Serves as a starting material for creating prodrugs with enhanced bioavailability and targeted delivery profiles.
• Biochemical Research: Employed in academic and industrial laboratories for studying glucocorticoid receptor activity and structure-activity relationships (SAR).
• Veterinary Medicine: Potential application in the development of anti-inflammatory treatments for animals.

Basic Information

Product Name	6α,9α-Difluoroprednisolone 17-Acetate
CAS No.	23674-85-3
Molecular Formula	C₂₃H₂₈F₂O₆
Molecular Weight	438.46 g/mol
Synonyms	6α,9α-Difluoro-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-acetate; 6α,9α-Difluoroprednisolone 21-acetate (common misnomer); 6α,9α-Difluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 17-acetate; Difluoroprednisolone Acetate; 6α,9α-Difluoroprednisolone acetate; Fluorinated Prednisolone Acetate Derivative; NSC 47433
EINECS	Contact for details

Quality Control

Our 6α,9α-Difluoroprednisolone 17-Acetate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical synthesis. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed HPLC purity profiles, identity confirmation (IR, NMR), and impurity limits. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.