Description

6Alpha,9-Difluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 17,21-Di(Acetate) CAS NO 23641-05-6 is a high-purity fluorinated corticosteroid derivative, serving as a critical pharmaceutical intermediate. Its primary value lies in its potent anti-inflammatory and immunosuppressive properties, which are foundational for advanced drug development. This compound is essential for research and manufacturing in the pharmaceutical industry, particularly for synthesizing topical and systemic corticosteroid medications.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the synthesis of potent topical corticosteroids like Difluprednate and other advanced steroid APIs.
• Anti-inflammatory Drug Research: Used in preclinical and clinical research to develop new treatments for inflammatory conditions such as dermatitis, psoriasis, and arthritis.
• Ophthalmic Solution Development: Critical for formulating ophthalmic suspensions and solutions targeting post-operative inflammation and uveitis.
• Dermatological Preparations: Incorporated into the development of creams, ointments, and gels for treating severe skin inflammation and allergic reactions.
• Biochemical Research: Utilized as a reference standard or probe in studies investigating glucocorticoid receptor activity and steroid metabolism pathways.
• Process Development & Scale-up: Serves as a benchmark compound for optimizing synthetic routes and purification processes in API manufacturing.

Basic Information

Product Name	6Alpha,9-Difluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 17,21-Di(Acetate)
CAS No.	23641-05-6
Molecular Formula	C₂₅H₃₀F₂O₇
Molecular Weight	480.50 g/mol
Synonyms	Difluprednate Impurity; Difluprednate Intermediate; 6α,9α-Difluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-diacetate; 6α,9-Difluoro-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-diacetate; Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,17,21-trihydroxy-, 17,21-diacetate, (6α,11β)-; (6α,11β)-6,9-Difluoro-11,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-diacetate
EINECS	Contact for details

Quality Control

Our 6Alpha,9-Difluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 17,21-Di(Acetate) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.