Description

6Alpha,9-Difluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 17-Butyrate is a synthetic corticosteroid derivative, specifically a fluorinated pregnadiene. This compound is a key pharmaceutical intermediate of significant commercial value due to its potent anti-inflammatory and immunosuppressive properties. It is primarily required by manufacturers in the pharmaceutical and biotechnology sectors for the research, development, and production of advanced topical and systemic corticosteroid medications.

Application

• Pharmaceutical Intermediate: Critical raw material for the synthesis of potent topical corticosteroids like difluprednate.
• Anti-inflammatory Drug Development: Serves as a core scaffold in R&D for novel drugs targeting inflammation, allergies, and autoimmune disorders.
• Ophthalmic Formulations: Used in the manufacture of eye drops and ointments for treating postoperative inflammation and uveitis.
• Dermatological Preparations: Key ingredient in the production of creams and ointments for eczema, psoriasis, and dermatitis.
• Biochemical Research: Used as a reference standard and probe in steroid receptor binding studies and metabolic pathway research.
• Veterinary Medicine: Employed in the development of anti-inflammatory treatments for animals.

Basic Information

Product Name	6Alpha,9-Difluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 17-Butyrate
CAS No.	23640-96-2
Molecular Formula	C25H31FO6
Molecular Weight	446.51 g/mol
Synonyms	Difluprednate Impurity; Difluprednate Intermediate; 6α,9α-Difluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 17-butyrate; 6α,9α-Difluoro-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione 17α-butyrate; 17-Butyryl-6α,9α-difluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione; Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,17,21-trihydroxy-, 17-butyrate, (6α,11β)-; (6α,11β)-6,9-Difluoro-11,17,21-trihydroxypregna-1,4-diene-3,20-dione 17-butyrate
EINECS	Contact for details

Quality Control

Our 6Alpha,9-Difluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 17-Butyrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.