Description

3'-Cyano-2,2,2-trifluoroacetophenone is a high-purity, versatile trifluoromethylated aromatic ketone building block. This compound is valued for its unique molecular scaffold, which combines an electron-withdrawing cyano group with a reactive trifluoroacetyl moiety, making it a critical intermediate in advanced synthetic chemistry. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for constructing complex molecules with tailored properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethyl groups to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of novel organic electronic materials, liquid crystals, and polymers with specific optical or electronic properties.
• Fluorine Chemistry Research: An essential reagent for academic and industrial research focused on introducing fluorine atoms into complex molecular architectures.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific synthesis projects.

Basic Information

Product Name	3'-Cyano-2,2,2-trifluoroacetophenone
CAS No.	23568-85-6
Molecular Formula	C9H4F3NO
Molecular Weight	199.13 g/mol
Synonyms	2,2,2-Trifluoro-1-(3-cyanophenyl)ethanone; 3-Cyanotrifluoroacetophenone; 1-(3-Cyanophenyl)-2,2,2-trifluoroethanone; 3'-Cyanotrifluoroacetophenone; 3-(Trifluoroacetyl)benzonitrile; α,α,α-Trifluoro-3-cyanoacetophenone; m-Cyanotrifluoroacetophenone; 3-Cyanophenyl trifluoromethyl ketone
EINECS	Contact for details

Quality Control

Our 3'-Cyano-2,2,2-trifluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen to prevent degradation. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.