Description

4'-Cyano-2,2,2-Trifluoroacetophenone is a versatile and high-value trifluoromethylated aromatic ketone building block. This compound is critical for introducing the trifluoroacetyl and cyano functional groups into complex molecular architectures, enabling the synthesis of advanced materials and active pharmaceutical ingredients. It is primarily sought by research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly those requiring the trifluoromethyl group for metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the CF3 group contributes to efficacy and environmental persistence.
• Ligand and Catalyst Precursor: Serves as a starting material for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and polymers where its electronic properties can be tuned.
• Fluorine Chemistry Research: An essential building block in academic and industrial R&D focused on exploring new fluorinated compounds and their unique chemical behaviors.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules on a commercial scale.

Basic Information

Product Name	4'-Cyano-2,2,2-Trifluoroacetophenone
CAS No.	23516-85-0
Molecular Formula	C9H4F3NO
Molecular Weight	199.13 g/mol
Synonyms	2,2,2-Trifluoro-1-(4-cyanophenyl)ethanone; 4-Cyanotrifluoroacetophenone; 1-(4-Cyanophenyl)-2,2,2-trifluoroethanone; 4'-Cyanotrifluoroacetophenone; p-Cyanotrifluoroacetophenone; α,α,α-Trifluoro-4-cyanoacetophenone; 4-(Trifluoroacetyl)benzonitrile; 4-Cyanophenyl trifluoromethyl ketone
EINECS	Contact for details

Quality Control

Our 4'-Cyano-2,2,2-Trifluoroacetophenone is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are provided and available upon request. We support compliance with global regulatory frameworks, including REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.