Description

1-(4-Chloro-Phenyl)-2-Isopropylamino-Ethanol is a versatile chiral intermediate and active pharmaceutical ingredient (API) building block. This compound is of significant commercial importance due to its role as a key precursor in the synthesis of β-adrenergic receptor antagonists (β-blockers). It is primarily required by pharmaceutical manufacturers and fine chemical synthesis companies for research, development, and production of cardiovascular and other therapeutic agents.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of β-blocker drugs such as propranolol and related analogues.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core building block for manufacturing APIs targeting adrenergic receptors.
• Fine Chemical Research: Used in R&D laboratories for developing new chiral compounds and exploring structure-activity relationships.
• Chemical Reference Standard: Employed as a high-purity standard for analytical method development and quality control in pharmaceutical analysis.
• Asymmetric Synthesis: Utilized in chiral synthesis and resolution processes due to its stereogenic center.

Basic Information

Product Name	1-(4-Chloro-Phenyl)-2-Isopropylamino-Ethanol
CAS No.	23299-13-0
Molecular Formula	C11H16ClNO
Molecular Weight	213.71 g/mol
Synonyms	4-Chloro-α-[(isopropylamino)methyl]benzyl alcohol; 1-(4-Chlorophenyl)-2-[(1-methylethyl)amino]ethanol; 1-(p-Chlorophenyl)-2-isopropylaminoethanol; Isopropylamino(4-chlorophenyl)ethanol; NSC 113928; Propranolol Intermediate; (±)-1-(4-Chlorophenyl)-2-[(1-methylethyl)amino]ethanol
EINECS	Contact for details

Quality Control

Our 1-(4-Chloro-Phenyl)-2-Isopropylamino-Ethanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity and impurity profile analysis, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with customer specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% (or as specified)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.