Description

Bupranolol is a potent, non-selective β-adrenergic receptor antagonist (β-blocker) used primarily in pharmaceutical research and development. This compound is critical for studying cardiovascular pharmacology and developing new therapeutic agents for conditions like hypertension, angina, and arrhythmias. It is an essential intermediate and reference standard for pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in drug discovery and analytical method development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced β-blocker drug substances and final dosage forms.
• Reference Standard: Used for quality control, method validation, and calibration in analytical laboratories (HPLC, GC, MS).
• Biochemical Research: A tool compound for investigating β-adrenergic receptor function, signal transduction pathways, and cardiac electrophysiology.
• Drug Discovery & Development: Serves as a lead compound or pharmacophore model for designing new cardiovascular and neurological therapeutics.
• Metabolite Studies: Used in the synthesis and identification of bupranolol metabolites for pharmacokinetic and toxicological profiling.
• Academic Research: Employed in university and institutional labs for pharmacological studies and educational purposes.

Basic Information

Product Name	Bupranolol
CAS No.	23284-25-5
Molecular Formula	C14H22ClNO2
Molecular Weight	271.79 g/mol
Synonyms	1-(tert-Butylamino)-3-(2-chloro-5-methylphenoxy)propan-2-ol; (±)-1-(tert-Butylamino)-3-(2-chloro-5-methylphenoxy)-2-propanol; DL-Bupranolol; KL 255; Betadran; Betadrenol; Looser
EINECS	245-548-5

Quality Control

Our Bupranolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity (HPLC), and impurity profiles are provided with every shipment. We support compliance with cGMP, ICH Q7, and relevant pharmacopeial guidelines for active pharmaceutical ingredients (APIs) and intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be kept under inert conditions for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.