Description

Adriamycin, also known as Doxorubicin, is a potent anthracycline antibiotic and antineoplastic agent. Its primary value lies in its critical role as a cornerstone chemotherapeutic drug for treating a wide spectrum of cancers. This compound is essential for pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) involved in oncology drug development and production.

Application

• Oncological Therapeutics: Primary active pharmaceutical ingredient (API) in injectable formulations for the treatment of various cancers, including breast cancer, leukemia, lymphoma, and sarcomas.
• Pharmaceutical Research & Development: Key reference standard and building block in preclinical and clinical studies for novel cancer therapies and combination regimens.
• Drug Product Manufacturing: Bulk API for the production of finished dosage forms such as lyophilized powders for injection or solution concentrates under Good Manufacturing Practice (GMP) conditions.
• Biochemical Research: Tool compound used in molecular biology and cell biology to study DNA intercalation, topoisomerase II inhibition, and mechanisms of apoptosis.
• Veterinary Medicine: Used in the formulation of chemotherapeutic treatments for certain cancers in animals.

Basic Information

Product Name	Adriamycin
CAS No.	23214-92-8
Molecular Formula	C₂₇H₂₉NO₁₁
Molecular Weight	543.52 g/mol
Synonyms	Doxorubicin; Doxorubicin Hydrochloride; 14-Hydroxydaunomycin; (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione; Adriamycin PFS; Adriamycin RDF; Hydroxydaunorubicin; FI-106
EINECS	245-495-6

Quality Control

Our Adriamycin is manufactured and tested to meet stringent pharmacopeial standards, including USP and EP monographs where applicable. Every batch undergoes comprehensive analytical testing for identity, purity, potency, and related substances. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring full traceability and compliance with cGMP guidelines for pharmaceutical active ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) or as specified. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	Orange-red, crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity: ≤ 1.0% Total impurities: ≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	Contact for details
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 5.0 EU/mg (for injectable grade)
Sterility (where applicable)	Sterile (for sterile API grade)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.