Description

(-)-Chlorpheniramine Maleate CAS NO 23095-76-3 is the specific levorotatory enantiomer of the widely used antihistamine, chlorpheniramine maleate, known for its superior pharmacological activity. This high-purity chiral intermediate is critical for ensuring the efficacy and safety of advanced pharmaceutical formulations. It is primarily required by manufacturers in the pharmaceutical industry for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and finished dosage forms.

Application

• Primary active ingredient in enantiomerically pure antihistamine medications.
• Key chiral intermediate for the synthesis of advanced pharmaceutical compounds.
• Used in research and development of new therapeutic agents targeting histamine H1 receptors.
• Essential component in the production of high-purity reference standards for analytical testing.
• Formulation of specialized cold, allergy, and anti-motion sickness preparations.
• Manufacturing of controlled-release and combination drug products.

Basic Information

Product Name	(-)-Chlorpheniramine Maleate
CAS No.	23095-76-3
Molecular Formula	C20H23ClN2O4
Molecular Weight	390.86 g/mol
Synonyms	Levocabastine Impurity G; (-)-(3S)-3-(4-Chlorophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine maleate; (S)-(-)-Chlorpheniramine Maleate; Levochlorpheniramine Maleate; L-Chlorpheniramine Maleate; Dexchlorpheniramine Maleate Impurity; (S)-Chlorpheniramine Maleate
EINECS	Contact for details

Quality Control

Our (-)-Chlorpheniramine Maleate is manufactured under strict quality management systems. We offer material compliant with pharmaceutical-grade standards, with rigorous testing for identity, purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing results for assay, enantiomeric excess, and related substances. Specifications can be aligned with client-specific pharmacopeial requirements (e.g., USP, EP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.