Description

Estradiol Bis[4-[Bis(2-Chloroethyl)Amino]Benzeneacetate] is a chemically modified derivative of estradiol, designed for targeted delivery and enhanced therapeutic potential. This compound matters as a key pharmaceutical intermediate in the development of advanced hormone-based therapies and research compounds. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of specialty active pharmaceutical ingredients (APIs) focused on oncology and endocrinology.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of specialized steroidal compounds and prodrugs for targeted therapy.
• Research & Development: Used in academic and industrial laboratories for studying hormone-receptor interactions and developing novel drug delivery systems.
• Oncology Research: Investigated for its potential application in the development of hormone-targeted chemotherapeutic agents due to its nitrogen mustard functional groups.
• Endocrinology Studies: Employed in research focused on estrogen signaling pathways and the design of hormone analogs.
• Prodrug Synthesis: Utilized in creating prodrugs where the estradiol moiety aids in tissue-specific targeting.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	Estradiol Bis[4-[Bis(2-Chloroethyl)Amino]Benzeneacetate]
CAS No.	22966-79-6
Molecular Formula	C38H46Cl4N2O4
Molecular Weight	728.60 g/mol
Synonyms	Estradiol 3,17β-bis[[p-[bis(2-chloroethyl)amino]phenyl]acetate]; Estradiol Mustard; NSC 112259; 17β-Estradiol bis(4-[bis(2-chloroethyl)amino]phenylacetate); Estradiol Nitrogen Mustard Ester; 1,3,5(10)-Estratrien-3,17β-diol 3,17-bis(4-[bis(2-chloroethyl)amino]phenylacetate); Estradiol-p-[bis(2-chloroethyl)amino]phenylacetate
EINECS	Contact for details

Quality Control

Our Estradiol Bis[4-[Bis(2-Chloroethyl)Amino]Benzeneacetate] is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. Keep the container in a dry, cool, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.