Description

11Beta,17,21-Trihydroxy-6Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-(Dihydrogen Phosphate) is a high-purity corticosteroid phosphate ester, a key pharmaceutical intermediate in the synthesis of potent anti-inflammatory and immunosuppressive agents. Its primary value lies in its role as a precursor for advanced steroid prodrugs, offering enhanced solubility and bioavailability profiles for targeted therapeutic formulations. This compound is essential for R&D and manufacturing teams in the pharmaceutical and biotechnology sectors, particularly those developing injectable or topical corticosteroid treatments.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of methylprednisolone sodium succinate and related potent corticosteroid APIs.
• Anti-inflammatory Drug Development: Used in R&D for creating next-generation injectable corticosteroid formulations with improved pharmacokinetics.
• Prodrug Synthesis: Serves as a building block for phosphate ester prodrugs designed to enhance water solubility and control drug release rates.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for HPLC or LC-MS method development and validation.
• Biochemical Research: Utilized in academic and industrial research to study glucocorticoid receptor interactions and steroid metabolism pathways.
• Veterinary Medicine: Component in the development of high-potency anti-inflammatory treatments for animal health.

Basic Information

Product Name	11Beta,17,21-Trihydroxy-6Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-(Dihydrogen Phosphate)
CAS No.	22252-38-6
Molecular Formula	C22H31O8P
Molecular Weight	454.46 g/mol
Synonyms	Methylprednisolone 21-Phosphate; 6α-Methylprednisolone 21-Phosphate; 11β,17,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-dihydrogen phosphate; U-67590A; NSC-19987; Medrate-21-Phosphate; 6α-Methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-(dihydrogen phosphate)
EINECS	Contact for details

Quality Control

Our 11Beta,17,21-Trihydroxy-6Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-(Dihydrogen Phosphate) is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards suitable for pharmaceutical R&D and intermediate use. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.