Description

3-(Difluoromethoxy)Nitrobenzene is a versatile fluorinated aromatic intermediate of significant importance in advanced organic synthesis. Its unique difluoromethoxy and nitro substituents make it a valuable building block for creating complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those requiring the difluoromethoxy pharmacophore for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the introduction of fluorine atoms can improve efficacy and environmental profile.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and liquid crystals with specific electronic or optical properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic aromatic substitutions, and reduction reactions to create more complex fluorinated aromatic compounds.
• Dye and Pigment Intermediate: Utilized in the synthesis of specialized dyes and pigments where the nitro group can be further transformed into amino or other functional groups.

Basic Information

Product Name	3-(Difluoromethoxy)Nitrobenzene
CAS No.	22236-07-3
Molecular Formula	C7H5F2NO3
Molecular Weight	189.12 g/mol
Synonyms	3-Nitro-α,α-difluoroanisole; 1-(Difluoromethoxy)-3-nitrobenzene; m-(Difluoromethoxy)nitrobenzene; 3-(Difluoromethoxy)-1-nitrobenzene; Benzene, 1-(difluoromethoxy)-3-nitro-; Nitro-3 difluoromethoxybenzene
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethoxy)Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.