Description

2-(Difluoromethoxy)Nitrobenzene is a specialized fluorinated aromatic intermediate of significant importance in advanced organic synthesis. Its unique difluoromethoxy substituent adjacent to a nitro group makes it a valuable precursor for constructing complex molecules with tailored properties. This compound is primarily sought by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the difluoromethoxy pharmacophore for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms can improve lipophilicity and biological activity.
• Material Science Research: Serves as a monomer or precursor in the development of specialty polymers and liquid crystals with specific electronic or optical properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions and nucleophilic aromatic substitutions to introduce functionalized benzene rings into more complex molecular architectures.
• Dye and Pigment Intermediate: Utilized in the synthesis of specialized nitroaromatic dyes and colorants.

Basic Information

Product Name	2-(Difluoromethoxy)Nitrobenzene
CAS No.	22225-77-0
Molecular Formula	C7H5F2NO3
Molecular Weight	189.12 g/mol
Synonyms	1-(Difluoromethoxy)-2-nitrobenzene; o-(Difluoromethoxy)nitrobenzene; 2-Nitrophenyl difluoromethyl ether; Benzene, 1-(difluoromethoxy)-2-nitro-; Nitrobenzene, 2-(difluoromethoxy)-; Difluoromethoxy Nitrobenzene
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.