Description

2,3-Difluorobenzonitrile is a high-purity fluorinated aromatic nitrile building block essential for advanced organic synthesis. This compound matters for its role as a key precursor in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the difluoro substitution pattern imparts specific electronic and steric properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries seeking to introduce fluorinated motifs into complex molecules.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing fluorinated drug candidates, particularly in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides where fluorine atoms enhance bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving dielectric anisotropy and performance.
• Polymer Modification: Incorporated as a monomer or additive to create specialty polymers with enhanced chemical resistance and thermal properties.
• Cross-Coupling Reactions: The nitrile and halogen groups make it a versatile substrate for Suzuki, Sonogashira, and other palladium-catalyzed coupling reactions.
• Organic Synthesis Research: A valuable reagent in academic and industrial labs for exploring novel fluorination chemistry and heterocycle formation.

Basic Information

Product Name	2,3-Difluorobenzonitrile
CAS No.	21524-39-0
Molecular Formula	C7H3F2N
Molecular Weight	139.10 g/mol
Synonyms	2,3-Difluorobenzonitrile; 2,3-Difluorophenyl cyanide; Benzonitrile, 2,3-difluoro-; 2,3-Difluorobenzene carbonitrile; 2,3-Difluorobenzonitril; 2,3-Difluorobenzonitril (German); 2,3-Difluorobenzonitrile (ACD/IUPAC Name); 2,3-Difluorobenzonitrile (VAN)
EINECS	Contact for details

Quality Control

Our 2,3-Difluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	45 - 50 °C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.