Description

2-Chloro-3-Fluoronitrobenzene is a high-purity halogenated nitrobenzene derivative, serving as a critical building block in advanced organic synthesis. Its precise molecular structure, featuring strategically placed chloro, fluoro, and nitro substituents, makes it an indispensable intermediate for creating complex molecules. This compound is primarily utilized by R&D chemists and process engineers in the pharmaceutical and agrochemical industries for the development of active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a specific halogenated aromatic core.
• Agrochemical Synthesis: Used in the manufacturing of herbicides, fungicides, and insecticides, where the nitro and halogen groups are leveraged for further functionalization.
• Material Science Research: Serves as a monomer or building block for developing novel polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate in the production of complex organic dyes and colorants.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination to create biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro group and halogen atoms facilitate substitution reactions to introduce amines, alkoxides, or other nucleophiles.

Basic Information

Product Name	2-Chloro-3-Fluoronitrobenzene
CAS No.	21397-07-9
Molecular Formula	C6H3ClFNO2
Molecular Weight	175.54 g/mol
Synonyms	1-Chloro-2-fluoro-3-nitrobenzene; 2-Chloro-1-fluoro-3-nitrobenzene; 3-Fluoro-2-chloronitrobenzene; 2-Fluoro-6-chloronitrobenzene; Benzene, 2-chloro-1-fluoro-3-nitro-; o-Chloro-m-fluoronitrobenzene; 2-Chloro-3-fluoronitrobenzene; 2-Chloro-3-fluoro-1-nitrobenzene
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-Fluoronitrobenzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our commitment to reliable supply and traceable quality supports your regulatory and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, open flames, and incompatible materials such as strong reducing agents and bases. The container should be kept tightly sealed when not in use to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.