Description

1-Fluoro-4-Nitro-2-(Trifluoromethylsulfonyl)Benzene is a high-value, multi-functional fluorinated aromatic building block. This compound matters for its unique combination of electron-withdrawing groups, making it a critical intermediate in advanced synthesis. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides requiring fluorinated aromatic cores.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and electronic materials where sulfonyl and nitro groups impart specific properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Sonogashira, and Buchwald-Hartwig amination reactions due to the activated fluorine atom.
• Organic Synthesis Building Block: Employed in nucleophilic aromatic substitution and as a scaffold for constructing complex heterocyclic compounds.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules in drug discovery and diagnostic assay development.

Basic Information

Product Name	1-Fluoro-4-Nitro-2-(Trifluoromethylsulfonyl)Benzene
CAS No.	20819-71-0
Molecular Formula	C7H3F4NO4S
Molecular Weight	273.16 g/mol
Synonyms	2-Fluoro-5-nitrobenzotrifluoride sulfone; 1-Fluoro-4-nitro-2-[(trifluoromethyl)sulfonyl]benzene; 2-Fluoro-5-nitro-α,α,α-trifluorobenzenemethanesulfonate; 2-Fluoro-5-nitro-α,α,α-trifluorotoluene-p-sulfonate; 2-Fluoro-5-nitrobenzyl trifluoromethyl sulfone; 2-Fluoro-5-nitro-α,α,α-trifluoromethyl phenyl sulfone; 2-Fluoro-5-nitrobenzotrifluoromethyl sulfone; 2-Fluoro-5-nitro-α,α,α-trifluorotoluene sulfone
EINECS	Contact for details

Quality Control

Our 1-Fluoro-4-Nitro-2-(Trifluoromethylsulfonyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.