Description

4-(Chloromethyl)-1-Fluoro-2-Nitro-Benzene is a versatile halogenated nitrobenzene derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring reactive chloromethyl, fluoro, and nitro substituents, makes it a valuable precursor for constructing complex molecular architectures. This intermediate is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in the development of fluorinated active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atom enhances biological activity and stability.
• Liquid Crystal & OLED Material Precursor: Employed in the synthesis of fluorinated aromatic compounds for electronic display and lighting applications.
• Dye & Pigment Manufacturing: Acts as an intermediate for creating specialized, high-performance colorants.
• Cross-Coupling Reactions: Serves as a substrate in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Polymer Modification: Used to introduce functional groups into polymer chains to alter physical or chemical properties.

Basic Information

Product Name	4-(Chloromethyl)-1-Fluoro-2-Nitro-Benzene
CAS No.	20274-70-8
Molecular Formula	C7H5ClFNO2
Molecular Weight	189.57 g/mol
Synonyms	1-Fluoro-2-nitro-4-(chloromethyl)benzene; 4-Chloromethyl-1-fluoro-2-nitrobenzene; 2-Nitro-4-chloromethylfluorobenzene; 4-(Chloromethyl)-2-fluoro-1-nitrobenzene; 2-Fluoro-4-(chloromethyl)-1-nitrobenzene; 1-Chloromethyl-4-fluoro-3-nitrobenzene; (2-Fluoro-5-nitrophenyl)methyl chloride
EINECS	Contact for details

Quality Control

Our production of 4-(Chloromethyl)-1-Fluoro-2-Nitro-Benzene adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.