Description

3,5-Difluoro-4-Hydroxy-Benzonitrile is a versatile fluorinated aromatic building block characterized by its benzonitrile core with hydroxyl and fluorine substituents. This compound matters for its role as a key intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its unique substitution pattern enables precise molecular design. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new compounds with targeted properties.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorine and cyano groups into polymer backbones, improving chemical resistance and thermal stability.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Chemical Research & Development: A valuable reagent for exploring new fluorination chemistry and constructing diverse chemical libraries for screening.

Basic Information

Product Name	3,5-Difluoro-4-Hydroxy-Benzonitrile
CAS No.	2967-54-6
Molecular Formula	C7H3F2NO
Molecular Weight	155.10 g/mol
Synonyms	4-Hydroxy-3,5-difluorobenzonitrile; 3,5-Difluoro-4-hydroxybenzonitrile; 2,6-Difluoro-4-cyanophenol; 4-Cyano-2,6-difluorophenol; Benzonitrile, 3,5-difluoro-4-hydroxy-; 2,6-Difluoro-4-hydroxybenzonitrile; DFHB
EINECS	Contact for details

Quality Control

Every batch of 3,5-Difluoro-4-Hydroxy-Benzonitrile is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards, and our quality control protocols include identity confirmation, purity assay, and impurity profiling. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and fluorides. The container must be kept tightly sealed due to potential moisture sensitivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	168°C - 172°C
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.