Description

21-Dehydro Dexamethasone Hydrate is a synthetic glucocorticoid derivative and a key intermediate in the synthesis of various steroid-based pharmaceuticals. This compound is valued for its role in research and development, enabling the creation of novel anti-inflammatory and immunosuppressive agents. It is primarily utilized by pharmaceutical manufacturers, research institutions, and fine chemical suppliers engaged in advanced steroid chemistry and drug discovery.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of dexamethasone and related corticosteroid APIs.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new glucocorticoid receptor modulators.
• Reference Standard: Serves as an analytical standard in quality control laboratories for HPLC or LC-MS method development and validation.
• Biochemical Research: Employed in studies investigating glucocorticoid metabolism, receptor binding affinity, and metabolic pathways.
• Fine Chemical Synthesis: Utilized for the custom synthesis of specialized steroid derivatives for clinical research and pre-clinical trials.

Basic Information

Product Name	21-Dehydro Dexamethasone Hydrate
CAS No.	2964-79-6
Molecular Formula	C22H29FO5 • xH2O
Molecular Weight	392.46 g/mol (anhydrous basis)
Synonyms	9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-Dehydro Derivative; 21-Dehydrodexamethasone; 1,4-Pregnadiene-9-fluoro-11β,17,21-triol-3,20-dione 16α-methyl-21-dehydro-; Dexamethasone 21-Dehydro Derivative; 16α-Methyl-9α-fluoro-1,4-pregnadiene-11β,17α,21-triol-3,20-dione 21-Dehydro
EINECS	Contact for details

Quality Control

Our 21-Dehydro Dexamethasone Hydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by IR spectroscopy, purity assay by HPLC, and control of related substances. A Certificate of Analysis (COA) detailing all test results is provided to ensure traceability and compliance with your research or manufacturing specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	Contact for details
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.