Description

Toliprolol is a selective β-1 adrenergic receptor antagonist, commonly known as a β-blocker. This compound is of significant interest in pharmaceutical research and development for its cardiovascular applications. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of active pharmaceutical ingredients (APIs) and the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the synthesis of β-blocker APIs.
• Cardiovascular Research: Used in preclinical and clinical research studies targeting hypertension and cardiac arrhythmias.
• Metabolite Studies: Serves as a reference standard or precursor in pharmacokinetic and metabolic pathway investigations.
• Analytical Standard: Employed as a high-purity standard for quality control (QC) and analytical method development (e.g., HPLC, LC-MS).
• Chemical Synthesis: Building block for medicinal chemists exploring novel compounds with adrenergic activity.
• Regulatory Submissions: Supplied for use in the preparation of documentation for regulatory bodies (e.g., FDA, EMA).

Basic Information

Product Name	Toliprolol
CAS No.	2933-94-0
Molecular Formula	C15H24N2O3
Molecular Weight	280.37 g/mol
Synonyms	1-(Isopropylamino)-3-(o-tolyloxy)-2-propanol; (±)-1-(Isopropylamino)-3-(o-tolyloxy)-2-propanol; Toliprolol Hydrochloride (salt form); DL-Toliprolol; BAY a 1043; o-Tolyloxy analogue of Propranolol; 2-Propanol, 1-[(1-methylethyl)amino]-3-(2-methylphenoxy)-
EINECS	220-915-5

Quality Control

Our Toliprolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are supplied with every shipment, detailing results for assay, related substances, and other critical parameters. Our quality standards are designed to meet the rigorous demands of pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.