Description

Methylprednisolone Hemisuccinate is a water-soluble ester prodrug of the potent glucocorticoid methylprednisolone, designed for enhanced parenteral administration. This compound is critical for delivering rapid and potent anti-inflammatory and immunosuppressive effects in acute clinical settings. It is an essential active pharmaceutical ingredient (API) primarily required by pharmaceutical manufacturers and compounding facilities for the production of injectable formulations.

Application

• Injectable Corticosteroid Formulations: Primary use in manufacturing lyophilized powders or solutions for intravenous or intramuscular injection.
• Acute Inflammatory Condition Management: Used in products for treating severe allergic reactions, asthma exacerbations, and acute episodes of autoimmune diseases.
• Immunosuppressive Therapy: A key component in formulations for managing organ transplant rejection and other immune-mediated disorders.
• Hospital & Emergency Medicine: Essential for ready-to-use solutions in critical care and emergency response for rapid systemic effect.
• Veterinary Pharmaceutical Products: Used in anti-inflammatory and immunosuppressive treatments for companion and livestock animals.
• Research & Development: Serves as a reference standard and building block in pharmacological and biochemical research exploring glucocorticoid pathways.

Basic Information

Product Name	Methylprednisolone Hemisuccinate
CAS No.	2921-57-5
Molecular Formula	C26H34O8
Molecular Weight	474.55 g/mol
Synonyms	Methylprednisolone 21-Hemisuccinate; U-67590A; 11β,17,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-hemisuccinate; 6α-Methylprednisolone 21-hemisuccinate; Solu-Medrol (as the sodium salt); Methylprednisolone Succinate; Medrate-S
EINECS	220-873-7

Quality Control

Our Methylprednisolone Hemisuccinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for assay and related substances, to ensure it meets high-purity standards suitable for pharmaceutical use. Certificates of Analysis (COA) are provided with each shipment, detailing compliance with in-house specifications aligned with major pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water (KF)	≤ 3.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.