Description

Prednisolone Succinate is a water-soluble ester prodrug of the potent glucocorticoid prednisolone, widely used in pharmaceutical formulations. This compound is critical for developing injectable and other aqueous-based therapeutic solutions where rapid systemic delivery of the active corticosteroid is required. It is an essential intermediate and active pharmaceutical ingredient (API) for manufacturers in the pharmaceutical and veterinary medicine industries, particularly for producing anti-inflammatory and immunosuppressive treatments.

Application

• Injectable Corticosteroid Formulations: Primary use as a water-soluble prodrug for intravenous (IV) or intramuscular (IM) injections, enabling rapid administration in hospital and clinical settings.
• Pharmaceutical Intermediates: Serves as a key synthetic intermediate in the production of various finished dosage forms of prednisolone and related steroid APIs.
• Anti-inflammatory Medications: Used in the development of treatments for severe allergic reactions, asthma exacerbations, and other inflammatory conditions requiring systemic corticosteroid therapy.
• Immunosuppressive Therapy: A component in formulations designed to manage autoimmune diseases and prevent organ transplant rejection.
• Veterinary Pharmaceuticals: Employed in veterinary medicine for similar anti-inflammatory and immunosuppressive applications in animals.
• Research & Development: Utilized in biochemical research and preclinical studies to investigate glucocorticoid receptor activity and metabolic pathways.

Basic Information

Product Name	Prednisolone Succinate
CAS No.	2920-86-7
Molecular Formula	C25H32O8
Molecular Weight	460.52 g/mol
Synonyms	Prednisolone 21-Hemisuccinate; Prednisolone Succinate Ester; 11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione 21-Hemisuccinate; Hydrocortisuc; Solu-Prednisolone (related to formulations); Prednisolone Hydrogen Succinate; NSC-106977; UNII-8B84082K1K
EINECS	220-870-9

Quality Control

Our Prednisolone Succinate is manufactured under strict quality management systems. We offer material compliant with pharmaceutical grade standards, suitable for API and intermediate use. Quality is assured through comprehensive analytical testing, including HPLC for assay and impurity profiling, residual solvent analysis, and specific identification tests. A Certificate of Analysis (COA) is provided with each batch, detailing compliance with agreed specifications. Our commitment ensures material traceability and consistency for your critical manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.