Description

4-[2-Hydroxy-3-[(1-Methylethyl)Amino]Propoxy]Phenol Hydrochloride is a high-purity pharmaceutical intermediate and research chemical. This compound is critical for the synthesis and development of β-adrenergic blocking agents (β-blockers), a major class of cardiovascular drugs. It is essential for pharmaceutical manufacturers, R&D laboratories, and academic institutions focused on cardiovascular research and active pharmaceutical ingredient (API) production.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of β-blocker APIs such as propranolol and related analogs.
• Cardiovascular Drug Research: Used in preclinical and clinical research for developing new adrenergic receptor antagonists.
• Chemical Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical labs.
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway studies of β-blocker drugs.
• Academic & Institutional Research: Used in university and institutional labs for medicinal chemistry and pharmacology studies.
• Process Development: Integral to scale-up and process optimization for the commercial manufacturing of β-blocker medications.

Basic Information

Product Name	4-[2-Hydroxy-3-[(1-Methylethyl)Amino]Propoxy]Phenol Hydrochloride
CAS No.	2829-84-7
Molecular Formula	C12H20ClNO3
Molecular Weight	261.75 g/mol
Synonyms	1-(Isopropylamino)-3-(4-hydroxyphenoxy)-2-propanol Hydrochloride; 4-[2-Hydroxy-3-(isopropylamino)propoxy]phenol Hydrochloride; Propranolol Impurity A Hydrochloride; 1-Isopropylamino-3-(p-hydroxyphenoxy)-2-propanol Hydrochloride; Desisopropyl Propranolol Hydrochloride; DL-1-(Isopropylamino)-3-(4-hydroxyphenoxy)-2-propanol Hydrochloride; 4-(2-Hydroxy-3-isopropylaminopropoxy)phenol Hydrochloride
EINECS	220-603-5

Quality Control

Our 4-[2-Hydroxy-3-[(1-Methylethyl)Amino]Propoxy]Phenol Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all test results against established specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical research and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure containers are kept tightly sealed to prevent absorption of atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Unknown Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.