Description

Flumethasone-17-Acetate CAS NO 2823-42-9 is a synthetic glucocorticoid corticosteroid, specifically a fluorinated derivative of prednisolone. This compound is a critical pharmaceutical intermediate and active pharmaceutical ingredient (API) with potent anti-inflammatory and immunosuppressive properties. It is primarily utilized by the pharmaceutical industry for the research, development, and manufacturing of topical and injectable corticosteroid formulations, as well as in veterinary medicine.

Application

• Primary use as an Active Pharmaceutical Ingredient (API) in the synthesis of topical corticosteroid creams, ointments, and lotions for treating dermatological conditions like eczema and psoriasis.
• Key intermediate in the production of veterinary pharmaceutical products, particularly for anti-inflammatory treatments in animals.
• Essential raw material for pharmaceutical research and development (R&D) of new glucocorticoid receptor agonists and related therapeutics.
• Used in the formulation of potent corticosteroid injections for managing severe inflammation and autoimmune disorders.
• Reference standard in analytical laboratories for quality control and method development using HPLC, LC-MS, or other chromatographic techniques.
• Starting material for the synthesis of more complex steroid derivatives and prodrugs in advanced medicinal chemistry.

Basic Information

Product Name	Flumethasone-17-Acetate
CAS No.	2823-42-9
Molecular Formula	C₂₄H₃₀FO₆
Molecular Weight	434.49 g/mol
Synonyms	Flumethasone 17-Acetate; 6α,9α-Difluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-Acetate; 6α,9α-Difluoro-16α-methylprednisolone 17-Acetate; NSC 107680; SQ 15102; Flumetasone 17-Acetate; Flumethasone Acetate (17-isomer)
EINECS	220-586-6

Quality Control

Our Flumethasone-17-Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. We provide detailed Certificates of Analysis (COA) that include results for identity, purity, and related substances, typically assessed by HPLC, IR, and other pharmacopeial methods. Our commitment to cGMP (current Good Manufacturing Practice) principles ensures consistent quality, traceability, and reliability for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants and maintaining conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.