Description

Pregna-1,4-Diene-3,20-Dione, 11,17-Dihydroxy-21-(Phosphonooxy)-, Monosodium Salt, (11Beta)- is a high-purity, water-soluble sodium phosphate ester derivative of a key corticosteroid intermediate. This compound is valued for its role as a critical synthetic precursor in the pharmaceutical industry, enabling the production of advanced anti-inflammatory and immunosuppressive agents. It is primarily required by manufacturers of active pharmaceutical ingredients (APIs) and research institutions engaged in steroid chemistry and novel drug development.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potent topical and systemic corticosteroids.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the production of steroid-based APIs for treating inflammatory and autoimmune conditions.
• Research & Development: Serves as a standard or starting material in medicinal chemistry research for developing new steroid analogues.
• Biochemical Research: Utilized in studies investigating glucocorticoid receptor interactions and metabolic pathways.
• Process Chemistry: Employed in scaling up and optimizing synthetic routes for steroid pharmaceuticals under GMP conditions.

Basic Information

Product Name	Pregna-1,4-Diene-3,20-Dione, 11,17-Dihydroxy-21-(Phosphonooxy)-, Monosodium Salt, (11Beta)-
CAS No.	2681-16-5
Molecular Formula	C21H28NaO8P
Molecular Weight	462.41 g/mol
Synonyms	21-Phosphonoxy-11β,17α-dihydroxypregna-1,4-diene-3,20-dione Monosodium Salt; 11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(Disodium Phosphate); Prednisolone 21-Phosphate Sodium Salt; Sodium Prednisolone Phosphate; Prednisolone Sodium Phosphate; NSC-100039; U-7532
EINECS	Contact for details

Quality Control

Our Pregna-1,4-Diene-3,20-Dione, 11,17-Dihydroxy-21-(Phosphonooxy)-, Monosodium Salt, (11Beta)- is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with cGMP, ICH Q7 guidelines, and relevant pharmacopeial standards (e.g., USP/EP monographs where applicable).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤3.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.