Description

Diflucortolone is a potent synthetic corticosteroid belonging to the glucocorticoid class, valued for its strong anti-inflammatory and antipruritic properties. This compound is a critical active pharmaceutical ingredient (API) for formulators requiring high-efficacy topical treatments. It is primarily utilized by pharmaceutical manufacturers in the development of prescription-strength dermatological creams, ointments, and lotions for managing severe skin conditions.

Application

• Topical Corticosteroid Formulations: Core API in prescription medications for treating severe eczema, psoriasis, and contact dermatitis.
• Dermatological Preparations: Used in creams, ointments, and lotions designed for anti-inflammatory and immunosuppressive effects on the skin.
• Veterinary Pharmaceuticals: Incorporated into topical treatments for inflammatory skin disorders in animals.
• Clinical Research: Serves as a reference standard in pharmacological studies and analytical method development.
• Compounding Pharmacy: Used by specialized pharmacies to prepare customized medication strengths for specific patient needs.

Basic Information

Product Name	Diflucortolone
CAS No.	2607-06-9
Molecular Formula	C22H28F2O4
Molecular Weight	394.46 g/mol
Synonyms	6α,9α-Difluoro-16α-methylprednisolone; 6α,9α-Difluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione; Diflucortolone Valerate (ester form); Nerisone (trade name); Nerisone Forte; Tricortone; Flucort; Diflucortoloni Valeras
EINECS	220-019-7

Quality Control

Our Diflucortolone is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical use, with specifications aligning with major pharmacopoeial guidelines. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to ensure regulatory compliance and supply chain transparency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.