Description

9-Fluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Valerate is a high-purity synthetic corticosteroid derivative, valued for its potent anti-inflammatory and immunosuppressive activity. This compound is a critical pharmaceutical intermediate, essential for the synthesis of advanced topical and systemic corticosteroid medications. It is primarily required by pharmaceutical R&D laboratories, active pharmaceutical ingredient (API) manufacturers, and fine chemical suppliers serving the global healthcare sector.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potent corticosteroid APIs, such as betamethasone valerate.
• Topical Corticosteroid Production: Used in manufacturing creams, ointments, and lotions for treating skin conditions like eczema, psoriasis, and dermatitis.
• Systemic Corticosteroid Development: Serves as a precursor for injectable or oral formulations targeting severe inflammatory and autoimmune disorders.
• Research & Development: Utilized in pharmacological studies to investigate glucocorticoid receptor activity and develop new anti-inflammatory agents.
• Veterinary Medicine: Applied in the development of anti-inflammatory treatments for animals.
• Reference Standard: Serves as an analytical standard for quality control and regulatory testing in pharmaceutical laboratories.

Basic Information

Product Name	9-Fluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Valerate
CAS No.	2600-31-9
Molecular Formula	C27H37FO6
Molecular Weight	476.58 g/mol
Synonyms	Betamethasone 17-Valerate; Betamethasone Valerate; Betnovate; Valisone; 9α-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-valerate; Celestoderm-V; Betamethasone 17-Valerate (USP); NSC-39471
EINECS	220-008-8

Quality Control

Our 9-Fluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Valerate is manufactured under strict quality management systems. It is produced to meet exacting standards suitable for pharmaceutical intermediate use, with typical purity levels exceeding 98.5% (by HPLC). Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We ensure compliance with relevant ICH guidelines and can support customer-specific validation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.