Description

1-(Diaminomethylidene)-3-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]Urea is a high-purity guanidine derivative of a ribose sugar, representing a critical building block in nucleoside chemistry. This compound is essential for the synthesis of modified nucleosides and nucleotides, which are fundamental to advanced pharmaceutical research and development. It is primarily sought by research institutions and pharmaceutical companies engaged in the discovery of antiviral agents, mRNA therapeutics, and novel diagnostic probes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside analogs for antiviral and anticancer drug discovery.
• Biochemical Research: Used in studies involving RNA modification, enzyme mechanisms, and the development of molecular probes.
• mRNA Vaccine & Therapeutic Development: Serves as a starting material for producing modified cap analogs or nucleoside triphosphates to enhance mRNA stability and translational efficiency.
• Diagnostic Reagent Synthesis: Employed in creating labeled nucleotides for sequencing, PCR, and other molecular biology techniques.
• Glycochemistry: Utilized as a specialized scaffold for synthesizing complex glycomimetics and carbohydrate-based molecules.

Basic Information

Product Name	1-(Diaminomethylidene)-3-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]Urea
CAS No.	2508-80-7
Molecular Formula	C7H14N4O6
Molecular Weight	250.21 g/mol
Synonyms	1-Carbamimidoyl-3-β-D-ribofuranosylurea; N-(Aminoiminomethyl)-N'-β-D-ribofuranosylurea; β-D-Ribofuranosyl-1-guanylurea; Guanidine, N-(β-D-ribofuranosyl)urea derivative; 1-Guanyl-3-β-D-ribofuranosylurea; Ribosylguanidine urea; (2R,3R,4R,5R)-2-(3-Carbamimidoylureido)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
EINECS	Contact for details

Quality Control

We supply this advanced intermediate under strict quality control protocols suitable for research and pharmaceutical applications. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. Our quality system supports compliance with cGMP standards for investigational pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.