Description

(2S,4R)-4-Fluoro-Pyrrolidine-2-Carboxylic Acid CAS NO 2507-61-1 is a high-purity, non-proteinogenic amino acid derivative featuring a fluorinated pyrrolidine scaffold. This compound is a critical chiral building block in modern medicinal chemistry, valued for its ability to modulate the physicochemical and metabolic properties of bioactive molecules. It is primarily sought after by pharmaceutical R&D and fine chemical synthesis teams for the development of novel therapeutics, including protease inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in protease inhibitor programs.
• Peptidomimetics: Used to construct fluorinated peptide analogs to enhance metabolic stability, bioavailability, and binding affinity.
• Organofluorine Chemistry: Serves as a versatile precursor for introducing the 4-fluoro-pyrrolidine motif into complex molecular architectures.
• Chemical Biology & Proteomics: Employed as a tool compound or building block for designing enzyme inhibitors and molecular probes.
• Agrochemical Research: Potential application in the development of novel, fluorinated active ingredients with improved properties.
• Academic & Contract Research: Utilized in research institutions and CROs for methodological development and discovery chemistry.

Basic Information

Product Name	(2S,4R)-4-Fluoro-Pyrrolidine-2-Carboxylic Acid
CAS No.	2507-61-1
Molecular Formula	C5H8FNO2
Molecular Weight	133.12 g/mol
Synonyms	(2S,4R)-4-Fluoropyrrolidine-2-carboxylic acid; 4-Fluoro-D-proline; (2S,4R)-4-Fluoro-2-pyrrolidinecarboxylic Acid; (4R)-4-Fluoro-L-proline; 4(R)-Fluoro-L-proline; 4-Fluoro-L-proline (trans isomer); 4-Fluoro-D-proline (cis isomer); 2507-61-1
EINECS	Contact for details

Quality Control

Our (2S,4R)-4-Fluoro-Pyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC, NMR, and MS, to ensure high enantiomeric purity and chemical identity. We provide Certificates of Analysis (COA) with detailed specifications for all critical parameters. Production can be aligned with cGMP guidelines for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.