Description

Dexamethasone 21-Phosphate Disodium Salt is a highly water-soluble phosphate ester derivative of the potent glucocorticoid dexamethasone. This derivative is critical for formulating injectable and ophthalmic solutions where rapid dissolution and bioavailability are paramount. It is an essential active pharmaceutical ingredient (API) and intermediate for manufacturers in the pharmaceutical, biotechnology, and advanced research sectors, serving as a cornerstone for anti-inflammatory and immunosuppressive therapies.

Application

• Pharmaceutical Formulations: Primary use as an active ingredient in injectable solutions for the treatment of severe allergic reactions, inflammatory conditions, and cerebral edema.
• Ophthalmic Solutions: Key component in eye drops and ointments for treating inflammatory eye disorders such as uveitis and allergic conjunctivitis.
• Veterinary Medicine: Used in anti-inflammatory and immunosuppressive treatments for companion and livestock animals.
• Biochemical Research: Serves as a critical tool compound for studying glucocorticoid receptor signaling, gene expression, and inflammatory pathways in vitro and in vivo.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, and pharmacopeial testing.
• Intermediate Synthesis: Acts as a protected or modified precursor in the synthesis of more complex steroid derivatives and prodrugs.

Basic Information

Product Name	Dexamethasone 21-Phosphate Disodium Salt
CAS No.	2392-39-4
Molecular Formula	C22H28FNa2O8P
Molecular Weight	516.39 g/mol
Synonyms	Dexamethasone Sodium Phosphate; Dexamethasone 21-(Disodium Phosphate); Dexamethasone Phosphate Disodium; 9α-Fluoro-16α-methylprednisolone 21-phosphate disodium salt; Oradexon; Decadron Phosphate; Dexasone; Hexadrol Phosphate; Spersadex; DXM-P-Na2
EINECS	219-222-1

Quality Control

Our Dexamethasone 21-Phosphate Disodium Salt is manufactured under strict quality management systems. We offer material compliant with major pharmacopeial standards, including USP and EP monographs. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring it meets the rigorous demands of pharmaceutical development and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 8.0%
pH (1% Solution)	7.5 - 9.0
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 0.17 EU/mg (for injectable grade)
Sterility	Sterile (for sterile-filtered grade)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.